SIMULTANEOUS TRIPLE-REGISTRATION OF ICTAL SPECT, INTERICTAL SPECT AND MR IMAGES FOR EPILEPSY STUDIES: METHOD AND VALIDATION (ThuPmOR2)

Author(s) : Erkan Unal Mumcuoglu (Middle East Technical University, Turkey) Fatih Nar (Middle East Technical University, Turkey) Yasemin Yardimci (Middle East Technical University, Turkey) Umut Kocak (Middle East Technical University, Turkey) Eser Lay Ergun (Nuclear Medicine Dep., Hacettepe University, Turkey) Belkis Erbas (Nuclear Medicine Dep., Hacettepe University, Turkey) Omer Ugur (Nuclear Medicine Dep., Hacettepe University, Turkey) Bilge Volkan Salanci (Nuclear Medicine Dep., Hacettepe University, Turkey)

Abstract : Subtraction of ictal and interictal SPECT images is known to be successful in localizing the seizure focus in presurgical evaluation of patients with partial epilepsy. Computer-aided method for producing subtraction ictal SPECT coregistered to MRI (SISCOM method) is commonly used. There are two registrations involved in SISCOM: between the ictal-interictal SPECT images, which was shown to be more critical, and between the ictal image and MRI. The aim of this paper is to improve registration accuracy of ictal-interictal registration in SISCOM by registering all three images (ictal, interictal SPECT, MRI) simultaneously. The results of the simulation study demonstrates that, in surface-based registration, triple-registration method results in smaller ictal-interictal SPECT registration error than the pairwise registration method (p<0.05) for a range of cost-function parameter values.

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